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CIMmultus® QA 8000 mL cGMP Compliant (1.3 μm)

CIMmultus® is a unique and industry-proven line of pre-packed chromatographic monolithic columns featuring large flow-through channels, designed for working with large biomolecules such as viruses (AAV, adenovirus, lentivirus, influenza, bacteriophages), nucleic acids (mRNA, pDNA), virus-like particles and exosomes. CIMmultus® columns can be used as single-use disposable or multi-use columns.

Item no.:  931.5113-1.3

Availability:  On Request

   

CIMmultus® Monoliths are reusable chromatography devices for scalable high-resolution purification of complex biological samples. Inside the custom designed housing is a single piece stationary phase with homogeneous channel size and surface chemistry. This stationary phase is designed to simplify method transfer from development into production.

Without the need for column packing, CIMmultus® Monoliths are ready for use out of the box.

This high-performance ion exchange column is primarily intended for fast and efficient purification of biomolecules such as large proteins, viruses and virus like particles through their ionic interaction with the monolith. The following information is being provided to ensure proper product care and optimal product performance.

QA (quaternary amine) features:

  • Strong anion exchanger
  • Working range, pH 2–13
  • Binds molecules with predominantly negative charge, repels molecules a predominantly positive charge
  • Use for capture, intermediate, or polishing steps in either bind-elute or flow-through mode
  • High capacity for virus particles, IgM, exosomes
  • High efficiency removal of endotoxin and DNA removal
  • Outstanding for preparative applications or analytical fingerprinting of process samples
  • Sanitizable with 1 M NaOH

Dimensions

  • Channel Size
    1.3 µm
  • Column Tube Length
    410 mm
  • Inner Diameter
    255 mm
  • Outer Diameter
    300 mm

General Specifications

  • Flow Rate
    1000–8000 mL/min | 15–135 cm/h | 0.15–1 CV/min

Operating Conditions

  • Maximum Operating Pressure
    0.7 MPa | 7 bar | 100 psi
  • Recommended Operating Temperature
    4 °C (39 °F) to 40 °C (104 °F)
  • pH Stability
    Working range 2–13, cleaning in place 1–14

eShop Dynamic Attributes

  • Bed Volume
    8000 mL
  • Chemical Compatibility
    All commonly used aqueous buffers, 1 M NaOH, 0.1 M HCl, 8 M urea, 6 M guanidine hydrochloride and 20 % ethanol solution. Avoid oxidising agents. Avoid prolonged exposure to concentrated acids (over 0.5 M) such as hydrochloric, sulphuric or acetic acids.
  • Connectors
    TC 1 in. (25 mm), 8 mm ID bore
  • Ligand
    QA (strong anion exchanger, quaternary amine)
  • Materials of Construction
    Poly(glycidyl methacrylate -co- ethylene dimethacrylate)
  • Package Type
    Individually Packed
  • Reusable
    Yes
  • Typical Dynamic Binding Capacity 10% per mL
    ≥ 20 mg BSA/mL wet support