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CIMac™ AAV full/empty 0.1 mL Analytical Column (1.3 µm)

CIMac™ Analytical Columns combine all elaborate characteristics of CIM monoliths at analytical scale and are your perfect tool for analysis and control of manufacturing processes, ideal for process analytical technology (PAT). Designed for fast and reproducible HPLC monitoring and quantitation of proteins, viruses, pDNA, and other large biomolecules, they allow you to achieve rapid, high-resolution and flow-independent separations in a matter of minutes.

Item no.:  110.8503-1.3

Availability:  On Request


The CIMac™ AAV full/empty 0.1 mL Analytical Columns are designed for fast and reproducible HPLC monitoring and quantitation of AAV samples. The high resolving capacity allows separation of empty viral capsids, aggregated and damaged particles from genome containing virus vectors. CIMac™ AAV full/empty-01 Analytical Column works with a full range of AAV serotypes and samples ranging from crude harvest all the way to final formulation, therefore doubling as an efficient PAT tool.

AAV full/empty features:

  • Strong anion exchanger
  • Enables fast and reproducible analysis and quantification in Adeno-associated virus (AAV)
  • Enables separation of empty and full virus capsids


  • Channel Size
    1.3 µm
  • Diameter
    5.2 mm

General Specifications

  • Flow Rate
    0.2 – 3 mL/min | 1 – 15 cm/min | 2 – 30 CV/min

Operating Conditions

  • Maximum Operating Pressure
    15 MPa | 150 bar | 2175 psi
  • Recommended Operating Temperature
    4 °C (39 °F) to 40 °C (104 °F)
  • pH Stability
    Working range 2–13, cleaning in place 1–14

eShop Dynamic Attributes

  • Bed Volume
    0.1 mL
  • Chemical Compatibility
    All commonly used aqueous buffers, 1 M NaOH, 0.1 M HCl, 8 M urea, 6 M guanidine hydrochloride and 20 % ethanol solution. Avoid oxidizing agents. Avoid prolonged use of concentrated acids (more than 0.5 M) like hydrochloric, sulphuric or acetic acid.
  • Connectors
    10-32 UNF coned port, 1/16’’ OD tubing connection
  • Ligand
    QA modified for AAV (strong anion exchanger, quaternary amine)
  • Materials of Construction
    Poly(glycidyl methacrylate -co- ethylene dimethacrylate)
  • Reusable