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CIMmultus® Oligo dT18 (C6 Linker) 400 mL cGMP (2 μm)

CIMmultus® is a unique and industry-proven line of pre-packed chromatographic monolithic columns featuring large flow-through channels, designed for working with large biomolecules such as viruses (AAV, adenovirus, lentivirus, influenza, bacteriophages), nucleic acids (mRNA, pDNA), virus-like particles and exosomes. CIMmultus® columns can be used as single-use disposable or multi-use columns.

Item no.:  924.1218-2

Availability:  On Request

   

CIMmultus® Monoliths are reusable chromatography devices for scalable high-resolution purification of complex biological samples. Inside the custom designed housing is a single piece stationary phase with homogeneous channel size and surface chemistry. This stationary phase is designed to simplify method transfer from development into production.

Without the need for column packing, CIMmultus® Monoliths are ready for use out of the box.

This high-performance ion exchange column is primarily intended for fast and efficient purification of biomolecules such as large proteins, viruses and virus like particles through their ionic interaction with the monolith. The following information is being provided to ensure proper product care and optimal product performance.

Oligo dT (deoxythymine) features:

  • Oligo dT ligands covalently bound to a solid support
  • Hybridises to the poly-adenylated tail which is present on most eukaryotic mRNAs, or synthetised onto the molecule during IVT
  • Primarily intended for fast and efficient capture and purification of mRNA with a poly-adenylated tail, from various sources
  • Can selectively remove impurities from the sample and is a convenient approach for initial purification of mRNA

Dimensions

  • Channel Size
    2 µm
  • Column Tube Length
    75 mm
  • Inner Diameter
    65 mm
  • Outer Diameter
    105 mm

General Specifications

  • Flow Rate
    100–800 mL/min | 30–245 cm/h | 0.25–2 CV/min

Operating Conditions

  • Maximum Operating Pressure
    1.4 MPa | 14 bar | 200 psi
  • Recommended Operating Temperature
    4 °C (39 °F) to 30 °C (86 °F)
  • pH Stability
    Linkage stability: pH 2–13. Ligand stability not tested. Functionality retained after exposure to 0.1 M NaOH for a few hours.

eShop Dynamic Attributes

  • Bed Volume
    400 mL
  • Connectors
    TC 1 in. (25 mm), 8 mm ID bore
  • Ligand
    • Oligo dT18 coupled to CDI-activated matrix, C6 Linker
    • C6 Linker
  • Ligand Density
    > 0.5 mg Oligo dT/mL wet support
  • Materials of Construction
    Poly(glycidyl methacrylate -co- ethylene dimethacrylate)
  • Package Type
    Individually Packed
  • Reusable
    Yes