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Ksep® Systems

Advanced, scalable, single-use automated centrifugation systems

Sartorius Ksep® systems provide robust, single-use bioprocessing solutions in the areas of recombinant therapeutics, cell therapy, vaccine manufacturing, and blood processing.

As per your process requirements, our fully-automated systems are optimized to recover supernatant or solids (cells | particles) in a continuous manner.

Ksep® systems solve the problems of traditional centrifugation and filtration based technologies by handling very high cell densities while providing high recoveries and product quality.

   

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Patented Ksep® systems technology is the only current technology that provides significant advantages for users that want to either harvest cells as product or discard cells as by-product during manufacturing.

Benefits

Smart Bioprocessing

  • Integrates and | or reduces processing steps and time
  • Improves recoveries of both solids and liquids
  • Provides option to selectively remove small particulate impurities, e.g. plastic generated, cell debris
  • Built-in scalability (4 – 6 fold) for development and manufacturing using the same system
  • Automated with option to run in complete manual mode
  • No hardware change for different applications
  • Handles low to high cell density cultures (>150 million cells/mL) equally well

Advanced Cell Handling

  • Imparts low shear on cells and keeps the cells intact
  • Maintains a healthy environment to sustain cell viability
  • Complete supernatant product recovery from slurry without dilution
  • Reduces intracellular protein contamination for harvest applications by keeping the cells intact

Ensures cGMP Manufacturing

  • Closed system with single-use class VI product contact surfaces
  • Simple, robust, and scalable
  • One software for all systems
  • Clog-free and continuous operation

Applications

  • Harvest | Clarification
  • Cell Therapy
  • Vaccine Manufacturing
  • Blood Processing
  • Learn more at www.sartorius.com/ksep-systems