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ambr® crossflow

Study factors for manufacturability

Collect important information about the behaviour of the molecules in downstream processing already in an early stage

Automated, parallel trials

Up to 16 channels can be managed by one control station

Lowest process volumes

Small scale screening with 10 cm² membrane area | 5 mL recirculation volume

Item no.:  061-8A01

 

Product Information
ambr® crossflow
The high throughput solution for parallel screening

ambr® crossflow provides at early development stages access to molecule behavior related to viscosity, buffer composition, shear stress and performance in membrane processes. It enables a lot of important additional decision criteria for the final candidate selection and speeds up this process significantly.

A small scale, high throughput automated system enables greater number of molecule | buffer combinations and process control conditions to be investigated. As a result early stage R&D productivity and efficiency will be improved significantly while costs per experiment are reduced.

ambr® crossflow is a benchtop crossflow system optimised for ultrafiltration and diafiltration applications. It is a small scale screening system with a minimum recirculation volume of 5 mL and a dedicated new range of ambr® CF filter cassettes with 10 cm² membrane area. Parallel operation is achieved with 4 independent crossflow channels per module, with up to 4 modules managed by one control station. This means ambr® crossflow is capable of performing membrane screenings with up to 16 ambr® CF filters simultaneously.

Intuitive hardware and software design ensures that the system is quick to set up and easy to use, while full system automation ensures reliable process control and reduced manual intervention.

Learn more at www.sartorius.com/ambr-crossflow

Application Note

Qualification of an Automated, High Throughput Crossflow System as a Scale-Down Model for Ultrafiltration and Diafiltration Process Development
en 1.2 MB
Evaluation of an Automated High Throughput Crossflow System as a Small-Scale Model of Bench Top Crossflow Filtration in Formulation Studies of Monoclonal Antibodies
en 367.2 kB

Dimensions

  • Dimensions WxDxH
    620 × 600 × 540 mm (4 channel module)

General Specifications

  • Pump Output
    0 – 50 mL/min

Materials of Construction

  • Recirculation Vessel
    Polystyrene (PS)

Operating Conditions

  • Maximum Operating Pressure
    3.5 bar (50 psi)
  • Minimum Operating Volume
    5 mL

Product Information

  • Brand
    ambr® crossflow

Volumes

  • Recirculation Vessel Volume
    100 mL
Ambr® CF Filter  Hydrosart®, 30 kD

The Ambr® CF Filter is a ready to use, fully disposable 10 cm² crossflow ultrafilter that is designed for high throughput membrane screening and formulation development. The Ambr® CF Filter is available with two membrane materials and in a wide variety of MWCO’s. The Ambr® CF Filter is designed to be used with the Ambr® crossflow system.

ambr® CF Filter  Hydrosart® 10 kD

The Ambr® CF Filter is a ready to use, fully disposable 10 cm² crossflow ultrafilter that is designed for high throughput membrane screening and formulation development. The Ambr® CF Filter is available with two membrane materials and in a wide variety of MWCO’s. The Ambr® CF Filter is designed to be used with the Ambr® crossflow system.

Ambr® Crossflow Adapter Kit for Sartocon® Slice 50

The Ambr® Crossflow Adapter Kit SC50 enables the use of Sartocon® Slice 50 with Ambr® Crossflow systems from software release R8.29.The reusable adapter kit is designed to accommodate four Sartocon® Slice 50 cassettes by redirecting feed, retentate, and permeate lines to the Sartocon® Slice 50 cassettes instead.

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