Hydrosart® high performance membrane is a stabilized cellulose based membrane that has been optimized for biopharmaceutical process applications.
- Hydrosart® is stable across a broad pH range.
- Hydrosart® is extremely hydrophilic, making it non-protein binding, and virtually non-fouling.
- Membrane cleaning, storage and depyrogenation can be accomplished by using NaOH even at elevated temperatures and concentrations.
These features make Hydrosart® an ideal membrane for biological applications.
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Hydrosart® is a stabilized cellulose derivative membrane polymer that has been optimized for the biotechnological and pharmaceutical industries. The Hydrosart® membrane is a stable polymer that features a broad pH and temperature range. Hydrosart is also extremely hydrophilic, making it non-protein binding and virtually non-fouling. As a result, it has extremely high flux. Hydrosart®’s wide temperature range makes it possible to sterilize the membrane by either steam or autoclaving. Membrane regeneration, storage and depyrogenation can be accomplished by using NaOH even at elevated temperatures. Hydrosart® membranes are designed for use in the biotechnological and pharmaceutical industries.
They can be used to remove the following from liquids:
Mammalian cells: CHO BHK
Bacteria: E. coli Pasteurella C. diphtheria
Cell Iysates Product
Hydrosart® has minimal adsorption of proteins, viruses, etc. Membrane retention is unaffected by repeated re-use. Hydrosart® has been validated to withstand in-line steam sterilization without any loss of integrity or changes in membrane retention.
Find Out Why Hydrosart® Crossflow Membranes are so Productive
Crossflow Filtration (also known as Tangential Flow Filtration, or TFF) is a filtration method used under dynamic flow conditions. Product feed flows tangentially along the surface of the membrane where the product molecule is retained, while buffer and contaminants pass through the membrane. Sartorius Crossflow Ultrafilters contain Hydrosart TFF Membranes of various molecular weight cut-offs to manage volume reduction and buffer exchange in antibody, vaccine, and blood & plasma processes. Hydrosart is the preferred and best performing TFF membrane for biopharmaceutical manufacturing.