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Virotag® AB and Virotag® DY reagents are labeling reagents for specific and precise quantification of viruses. The Virotag® AB reagent family utilizes a fluorescently labeled, high-affinity antibody which binds to a unique viral epitope. Quantification of viruses using Virotag® is independent of the presence of nucleic acid. The Virotag® DY reagents stains viral genomes and viral envelope proteins with a combination of two fluorogenic dyes. When fluorescent emission is simultaneously observed in both channels, this ‘simultaneous event’ is counted as one intact particle.