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Sartobind® Q

Sartobind® Q strong ion exchangers are perfect tools for the polishing of monoclonal antibodies for the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins. As size exclusion effects are neglectible, they are suited for purification of viruses such as adeno or lentiviruses displaying one order of magnitude higher dynamic binding capacity.

Sartobind® Q 400 mL, 4 mm bed height

Sartobind® Q strong ion exchangers are perfect tools for the polishing of monoclonal antibodies for the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins. As size exclusion effects are neglectible, they are suited for purification of viruses such as adeno or lentiviruses displaying one order of magnitude higher dynamic binding capacity.

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Sartobind® Q 400 mL, 8 mm bed height

Sartobind® Q strong ion exchangers are perfect tools for the polishing of monoclonal antibodies for the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins. As size exclusion effects are neglectible, they are suited for purification of viruses such as adeno or lentiviruses displaying one order of magnitude higher dynamic binding capacity.

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Sartobind® Q SingleSep Mini
Sartobind® Q SingleSep Mini
Item no.: 92IEXQ42D4-SS--A

Sartobind® Q strong ion exchangers are perfect tools for the polishing of monoclonal antibodies for the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins. As size exclusion effects are neglectible, they are suited for purification of viruses such as adeno or lentiviruses displaying one order of magnitude higher dynamic binding capacity.

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Sartobind® Q Cassette 1.6 L, 8 mm bed height

Sartobind® Q strong ion exchangers are perfect tools for the polishing of monoclonal antibodies for the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins. As size exclusion effects are neglectible, they are suited for purification of viruses such as adeno or lentiviruses displaying one order of magnitude higher dynamic binding capacity.

The cassette design eliminates the 5 L size limitation for membrane adsorbers and offers simple pod-like modular system up to 100 L membrane volume.

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Sartobind® Q 150 mL, 8 mm bed height

Sartobind® Q strong ion exchangers are perfect tools for the polishing of monoclonal antibodies for the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins. As size exclusion effects are neglectible, they are suited for purification of viruses such as adeno or lentiviruses displaying one order of magnitude higher dynamic binding capacity.

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Sartobind® Q membrane adsorbers display a macro-porous structure with pore size of > 3 µm. Quaternary ammonium ligands are bound covalently to the complete internal surface of the membrane, resulting in separation media of high binding capacity combined with exceptional high flow rates.

Applications virus and VLP capture:

As size exclusion effects are negligible, they are suited for purification of viruses and display one order of magnitude higher dynamic binding capacity compared to resin. Viruses such as adeno- or lentiviruses are captured at high flow rates. The material allows also >100 cycles of re-use without loss of binding capacity.

Benefits capture:

  • High speed purification at 5 - 30 bed volumes per minute
  • No size exclusion effects for large proteins an viruses / VLPs
  • >10fold higher binding capacities compared to conventional resins

Applications flow-through polishing:

Sartobind Q is the perfect tool for the flow-through polishing of valuable proteins such as monoclonal antibodies. The bed volumes can be kept sufficiently small during the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins from such pharmaceutical proteins.

Benefits flow-through polishing:

  • Virus clearance > 6 log
  • DNA below detection limit
  • Host cell protein removal > 99 %
  • Endotoxin removal > 5 log
  • Save 80 % of column costs

Easy to use:

  • Plug and play devices from 0.08 mL to 5 L
  • Can be used like a filter
  • Flow rate up to 30 bed volumes/min
  • Re-usable or disposable

Application Note

High Throughput Screening using Membrane Chromatography — Membrane based 96-well plate for process development in biomanufacturing
en 1.0 MB
Sartobind ® Capsules for Capture and Polishing
en 811.2 kB
Host cell protein removal — A comparison between Sartobind STIC® PA and Sartobind Q
en 553.7 kB
DNA Removal using Sartobind® Q in mAb Purification — Ion Exchange Chromatography with Sartobind® Membrane Adsorbers
en 276.8 kB
Scale up with Sartobind® Q pico — Miniaturized scaleable format for process developers
en 670.2 kB
Optimizing Adenovirus Purification Processes Using Sartobind® Q and STIC PA anion exchange membranes
en 789.3 kB
1000 cycles constant binding capacity - Sartobind® Q anion exchanger
en 428.1 kB
Endotoxin Removal — Ion Exchange Chromatography with Sartobind® Membrane Adsorbers
en 123.6 kB
Virus Purification and Removal — Ion Exchange Chromatography with Sartobind® Membrane Adsorbers
en 710.9 kB

Brochure

Sartobind® Membrane Adsorbers — Chromatography as easy as filtration
en 3.7 MB

Datasheet

Sartobind® Q and S, 4 and 8 mm bed height
en 1.7 MB
Sartobind® 96-well plates — High Throughput Screening with IEX and HIC Membrane Chromatography
en 843.2 kB
Sartobind® pico 0.08 mL — Membrane chromatography tool for process development
en 231.9 kB

Flyer

Sartobind® selection guide
en 1.0 MB

User Manual

Void Volume Optimized Capsules and Cassettes With 4 | 8 mm Bed Height
en 423.2 kB
Sartobind® 96-well plates — IEX (Q, S, STIC PA) and HIC (Phenyl) in 8-strips — For High Throughput Screening Based on Macroporous Membranes, 0.8 mm Bed Height
en 300.6 kB
Manual Sartobind pico 0.08 mL
en 686.8 kB