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Sartobind® S Jumbo 5 L, 8 mm bed height

Sartobind® S membrane adsorber units combine the advantages of convective media and ion exchange chromatography for rapid and easy contaminant removal or capture of virus and virus like particles.

Order Number:  96IEXS42E3ESS

Availability:  On Request

Sartobind® S membrane adsorbers display a macro-porous structure with pore size of > 3 µm. Sulfonic acid ligands are bound covalently to the complete internal surface of the membrane, resulting in separation media of high binding capacity combined with exceptional high flow rates.

Applications:

The S membrane adsorber is successfully used in FDA-approved drug manufacture to remove host cell proteins at high flow rates. As a cation exchanger it displays not only aggregate removal capabilities but typically at least ten-fold higher binding capacity for viruses and virus-like-particles (VLP).

Benefits:

The Sartobind S adsorber speeds up the production process by high flow rate and opens new opportunities for the purification of therapeutic proteins and vaccines.

  • High speed host cell protein removal up to 30 bed volumes/ min
  • Aggregate removal

Easy to use:

  • Plug and play devices from 0.08 ml to 5 l
  • Can be used like a filter
  • Flow rate up to 30 bed volumes/min
  • Disposable or re-usable

Application Note

Sartobind ® Capsules for Capture and Polishing
en 1.1 MB

Brochure

Sartobind® Membrane Adsorbers — Chromatography as easy as filtration
en 3.7 MB

Flyer

Sartobind® selection guide
en 1.0 MB

User Manual

Sartobind® Q and S Membrane Adsorbers — Void Volume Optimized Capsules With 4 | 8 mm Bed Height
en 1.3 MB

Product properties

  • Connector Inlet
    Sanitary 1 - 1 ½"
  • Connectors
    Sanitary 1 - 1 1/2"
  • Pore size final-filter
    3 – 5 µm
  • Bed volume
    5,000 mL
  • Bed height
    8 mm
  • Flow rate
    25 L/min
  • Membrane area
    18.2 m²
  • Primary Product Type
    Membranes
  • Type
    Membrane adsorber
  • Design
    Optimized design
  • Application
    Capturing and polishing
  • Pack size
    1
  • Membrane filter material
    Stabilised reinforced cellulose
  • Membrane material
    Stabilised reinforced cellulose
  • Membrane
    Strong cation exchanger
  • Filter Format
    Capsules

Technical attributes

  • Dimensions (WxDxH)
    30.2 × 85 cm
  • Maximum Pressure
    0.3 MPa
  • Thermal stability
    Sartobind capsules with ion exchange membranes can be autoclaved at 121 °C for 30 min. We recommend one autoclaving cycle only.
  • Ligand density
    2 – 5 µeq/cm²
  • Void volume
    7 L
  • Typical dynamic binding capacity 10% per unit
    127 g
  • Maximum Venting Pressure
    0.5 bar, 0.05 MPa, 7 psi
  • Recommended flow rate
    25 L/min
  • Chemical compatibility
    Stable in common chromatography buffers, unstable to peroxide and other oxidizing or reactive reagents
  • Reference protein
    Lysozyme
  • Application
    Capturing` Polishing
  • Biosafety
    All materials of this filter element meet the requirements of the current USP Biological Reactivity tests <88> for plastics Class VI (Systemic Injection, Intracutaneous and Implantation tests).
  • What you receive
    1 capsule` 15 membrane discs 30 mm` 1 operating instructions` 1 certificate
  • Materials of Construction
    Polypropylene, polyester
  • Housing material
    Polypropylene (PP)
  • Ligand
    Sulfonic acid
  • pH stability
    pH 3 – 14 (short term), pH 4 – 13 (long term)
  • Reusable
    Yes
  • Membrane type
    Strong cation exchange membrane