Sartocon® Cassette | PES | 300kDa | 0.7m²

  • Membrane Material: Polyethersulfone
  • Effective Filtration Area: 0.7m²
  • Cut-Off: 300 kDa
  • Screen Type: E-Screen (High viscosity)

Sartocon® TFF cassettes with Polyethersulfone membranes are designed for use in the biotechnological and pharmaceutical industries.

Price (USD):
$3,770.00
Item No.: 
3021467907E--SW
Piece
1

*Custom/bulk order quotes are provided within 72 hours of request.

Sartocon® Polyethersulfone TFF cassettes are well established in the biotechnological and pharmaceutical industry. The PES membrane is a stable polymer that features a broad pH and temperature range. Membrane regeneration, storage and depyrogenation can be accomplished by using NaOH even at elevated temperatures.

Sartocon® cassettes are self-sealing, feature low extractables and the enlarged feed and retentate ports lower system pressure drops.

Sartocon® cassettes are ideally combined with Sartorius Sartocon holders and systems.

Applications

Typical 300 kDa TFF Applications are Ultrafiltration and Diafiltration of

  • Large Viruses such as MVA for Smallpox and Monkeypox vaccine
  • Virus like particles
  • pDNA and mRNA
  • Blood and Plasma
  • Protein solutions
  • Polysaccharide solutions
  • Large mAb constructs
  • Removal of Contaminants

Polyethersulfone Membrane

Polyethersulfone (PES) membrane is an established membrane polymer that is well suited to any biopharmaceutical process applications. PES membrane is a stable polymer that can operate in a broad pH and temperature range and withstand aggressive cleaning cycles.

Flow Channel Geometry

The Sartocon® family is available in two flow channel geometry versions. E-Screen filters are dominantly used for protein concentrations up to above 20% as well as viscosity conditions greater than 3 cp. ECO-Screen devices mainly used for water based protein solutions of below 20% protein concentration as well as lower than 3 cp viscosity allow economical optimized filtration runs.

Available Sizes and Cut-Offs

Sartorius Sartocon® and Sartocube® TFF cassettes are available for pilot- and production scale, and in Sartocon® Slice as well as Sartocon® Slice 200 format for reduced volume handling.

Cut-Offs:

E-screen: 1 | 5 | 8 | 10 | Albumin | 30 | 50 | 100 | 300 kDa

ECO screen: 10 | 30 | 100 | 300 kDa

Regulatory Compliance

All product contact materials have passed the current USP Biological Test and Cytotoxicity Test. All materials are BSE and TSE free. The filtrate meets or exceeds the currently valid USP and EP for sterile Water for Injection, with respect to extractable substances, oxidizable substances and Bacteria Endotoxins.

Applications

  • Industry
    Pharma / Biotech  

Compliance Information

  • Bacterial Endotoxins
    < 0.18 EU/mL as determined by the LAL test  
  • Biological Reactivity
    All materials of this filter element meet the requirements of the current USP Biological Reactivity tests <88> for plastics Class VI (Systemic Injection, Intracutaneous and Implantation tests).  
  • Extractables
    The total amount of extractables is well below the limits established by the current USP unter "Sterile Water for Injection".  

Dimensions

  • Filtration Area
    0.7 m²  
  • Flow Channel Geometry
    Protein conc. >20% /or viscosity above.3cp  

General Specifications

  • Cassette Format
    Sartocon Cassettes  
  • Filter Class
    Ultrafilter  
  • Filter Configuration
    Sartocon Cassette  
  • Filter Format
    Cassettes  
  • Ultrafilter
    300 kD Polyethersulfone Ultrafilter Membrane  

Materials of Construction

  • Integral Frame
    Polyvinylidene fluoride (PVDF)  
  • Membrane Material
    Polyethersulfone (PES)  
  • Sealing Compound
    Silicone White (High chemical resistance)  
  • Spacer
    Polypropylene (PP)  

Operating Conditions

  • Maximum Inlet Pressure
    4 bar  
  • pH Stability
    pH 1 – 14  

Physicochemical Information

  • MWCO
    300 kDa  
  • Non-Fiber Releasing
    This filter product complies with the title 21 of the Code of Federal Regulations (CFR), section 210.3(b)(6) and 211.72.  

Product Information

  • Brand
    Sartocon®  
  • Pack Size
    1  
  • Type
    0.7m² | E-Screen  
  • Sartoflow® 20, 1.4435, F/R38/P26, DIN

    The Sartoflow® 20 stainless steel holder with hydraulic is designed for TFF applications from 200 L to 2500 L volumes. The holder is optimized for use with 4 Sartocon® up to 20 Sartocube® production scale TFF cassettes (max. 14 m2). Typical applications of the Sartoflow® 20 system includes concentration and diafiltration of proteins, vaccines, antibodies, oligo nucleotides, endotoxin removal etc., cell harvesting and clarification processes.