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Sartobind® S Jumbo 5 L, 8 mm bed height

Sartobind® S membrane adsorber units combine the advantages of convective media and ion exchange chromatography for rapid and easy contaminant removal or capture of virus and virus like particles.

Item no.:  96IEXS42E3ESS

Availability:  On Request

Sartobind® S membrane adsorbers display a macro-porous structure with pore size of > 3 µm. Sulfonic acid ligands are bound covalently to the complete internal surface of the membrane, resulting in separation media of high binding capacity combined with exceptional high flow rates.

Applications:

The S membrane adsorber is successfully used in FDA-approved drug manufacture to remove host cell proteins at high flow rates. As a cation exchanger it displays not only aggregate removal capabilities but typically at least ten-fold higher binding capacity for viruses and virus-like-particles (VLP).

Benefits:

The Sartobind S adsorber speeds up the production process by high flow rate and opens new opportunities for the purification of therapeutic proteins and vaccines.

  • High speed host cell protein removal up to 30 bed volumes/ min
  • Aggregate removal

Easy to use:

  • Plug and play devices from 0.08 ml to 5 l
  • Can be used like a filter
  • Flow rate up to 30 bed volumes/min
  • Disposable or re-usable

Application Note

Sartobind ® Capsules for Capture and Polishing
en 811.2 kB

Brochure

Sartobind® Membrane Adsorbers — Chromatography as easy as filtration
en 3.7 MB

Datasheet

Sartobind® Q and S, 4 and 8 mm bed height
en 1.7 MB

Flyer

Sartobind® selection guide
en 1.0 MB

User Manual

Void Volume Optimized Capsules and Cassettes With 4 | 8 mm Bed Height
en 423.2 kB

Product properties

  • Design
    Optimized design
  • Primary Product Type
    Membranes
  • Type
    Membrane adsorber
  • Connectors
    Sanitary 1 - 1 ½"
  • Filter Format
    Capsules
  • Flow Rate
    25 L/min
  • Pore Size Final-filter
    3 – 5 µm
  • Bed Height
    8 mm
  • Bed Volume
    5,000 mL
  • Membrane
    Strong cation exchanger
  • Membrane Area
    18.2 m²
  • Membrane Material
    Stabilised reinforced cellulose
  • Pack Size
    1

Technical attributes

  • Chemical Compatibility
    Stable in common chromatography buffers, unstable to peroxide and other oxidizing or reactive reagents
  • Reference Protein
    Lysozyme
  • Reusable
    Yes
  • Biosafety
    All materials of this filter element meet the requirements of the current USP Biological Reactivity tests for plastics Class VI (Systemic Injection, Intracutaneous and Implantation tests).
  • Housing Material
    Polypropylene (PP)
  • Ligand
    Sulfonic acid
  • Materials of Construction
    Polypropylene, polyester
  • What you receive
    • 1 capsule
    • 15 membrane discs 30 mm
    • 1 operating instructions
    • 1 certificate
  • Recommended Flow Rate
    25 L/min
  • Typical Dynamic Binding Capacity 10% per unit
    127 g
  • Void Volume
    7 L
  • Maximum Pressure
    0.3 MPa
  • pH Stability
    pH 3 – 14 (short term), pH 4 – 13 (long term)
  • Membrane Type
    Strong cation exchange membrane
  • Application
    • Capturing
    • Polishing
  • Dimensions (W×D×H)
    30.2 × 85 cm
  • Ligand Density
    2 – 5 µeq/cm²
  • Maximum Venting Pressure
    0.5 bar, 0.05 MPa, 7 psi
  • Thermal Stability
    Sartobind capsules with ion exchange membranes can be autoclaved at 121 °C for 30 min. We recommend one autoclaving cycle only.