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Sartobind® S Cassette 0.8 L, 4 mm bed height

Sartobind® S membrane adsorber units combine the advantages of convective media and ion exchange chromatography for rapid and easy contaminant removal or capture of virus and virus like particles.

The cassette design eliminates the 5 L size limitation for membrane adsorbers and offers simple pod-like modular system up to 100 L membrane volume.

Item no.:  98IEXS42D-L

Availability:  On Request

Sartobind® S membrane adsorbers display a macro-porous structure with pore size of > 3 µm. Sulfonic acid ligands are bound covalently to the complete internal surface of the membrane, resulting in separation media of high binding capacity combined with exceptional high flow rates.

Applications:

The S membrane adsorber is successfully used in FDA-approved drug manufacture to remove host cell proteins at high flow rates. As a cation exchanger it displays not only aggregate removal capabilities but typically at least ten-fold higher binding capacity for viruses and virus-like-particles (VLP).

Benefits:

The Sartobind S adsorber speeds up the production process by high flow rate and opens new opportunities for the purification of therapeutic proteins and vaccines.

  • High speed host cell protein removal up to 30 bed volumes/ min
  • Aggregate removal

Easy to use:

  • Plug and play devices from 0.08 ml to 5 l
  • Can be used like a filter
  • Flow rate up to 30 bed volumes/min
  • Disposable or re-usable

Application Note

Sartobind ® Capsules for Capture and Polishing
en 811.2 kB

Brochure

Sartobind® Membrane Adsorbers — Chromatography as easy as filtration
en 3.7 MB

Datasheet

Sartobind® Q and S, 4 and 8 mm bed height
en 1.7 MB

Flyer

Sartobind® selection guide
en 1.0 MB

User Manual

Void Volume Optimized Capsules and Cassettes With 4 | 8 mm Bed Height
en 423.2 kB

Product properties

  • Connectors
    Sanitary 1 - 1 ½" via Manifold
  • Pore size final-filter
    3 – 5 µm
  • Bed volume
    0.8 L
  • Bed height
    4 mm
  • Flow rate
    16 L/min
  • Membrane area
    2.9 m²
  • Primary Product Type
    Membranes
  • Type
    Membrane adsorber
  • Design
    Cassette design
  • Pack Size
    1
  • Membrane Material
    Stabilised reinforced cellulose
  • Membrane
    Strong cation exchanger
  • Filter Format
    Cassettes

Technical attributes

  • Dimensions (WxDxH)
    634 × 49 × 387 mm
  • Maximum Pressure
    0.2 MPa
  • Thermal stability
    Sartobind cassettes with ion exchange membranes cannot be autoclaved, but they can be gamma irradiated.
  • Ligand Density
    2 – 5 µeq/cm²
  • Maximum Venting Pressure
    0.5 bar, 0.05 MPa, 7 psi
  • Chemical Compatibility
    Stable in common chromatography buffers, unstable to peroxide and other oxidizing or reactive reagents
  • Reference Protein
    Lysozyme
  • Application
    Polishing
  • Biosafety
    All materials of this filter element meet the requirements of the current USP Biological Reactivity tests for plastics Class VI (Systemic Injection, Intracutaneous and Implantation tests).
  • What you receive
    • 1 cassette
    • 1 operating instruction
    • 1 certificate
  • Materials of Construction
    Polyester
  • Housing Material
    Acrylonitrile butadiene styrene (ABS)
  • Ligand
    Sulfonic acid
  • pH Stability
    pH 3 – 14 (short term), pH 4 – 13 (long term)
  • Reusable
    Yes
  • Membrane Type
    Strong cation exchange membrane
  • Typical Dynamic Binding Capacity 10% per unit
    23.2 g
  • Void Volume
    2.5 L