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Sartobind® Q pico 0.08 mL

Sartobind® Q strong ion exchangers are perfect tools for the polishing of monoclonal antibodies for the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins. As size exclusion effects are neglectible, they are suited for purification of viruses such as adeno or lentiviruses displaying one order of magnitude higher dynamic binding capacity.

Item no.:  92IEXQ42DD-11--D

Availability:  On Request

Sartobind® Q membrane adsorbers display a macro-porous structure with pore size of > 3 µm. Quaternary ammonium ligands are bound covalently to the complete internal surface of the membrane, resulting in separation media of high binding capacity combined with exceptional high flow rates.

Applications virus and VLP capture:

As size exclusion effects are negligible, they are suited for purification of viruses and display one order of magnitude higher dynamic binding capacity compared to resin. Viruses such as adeno- or lentiviruses are captured at high flow rates. The material allows also >100 cycles of re-use without loss of binding capacity.

Benefits capture:

  • High speed purification at 5 - 30 bed volumes per minute
  • No size exclusion effects for large proteins an viruses / VLPs
  • >10fold higher binding capacities compared to conventional resins

Applications flow-through polishing:

Sartobind Q is the perfect tool for the flow-through polishing of valuable proteins such as monoclonal antibodies. The bed volumes can be kept sufficiently small during the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins from such pharmaceutical proteins.

Benefits flow-through polishing:

  • Virus clearance > 6 log
  • DNA below detection limit
  • Host cell protein removal > 99 %
  • Endotoxin removal > 5 log
  • Save 80 % of column costs

Easy to use:

  • Plug and play devices from 0.08 mL to 5 L
  • Can be used like a filter
  • Flow rate up to 30 bed volumes/min
  • Re-usable or disposable

Application Note

Using the Sartobind® pico — Optimizing Steps for using micro-scale membrane adsorbers on liquid chromatography systems
en 1.5 MB
Scale up with Sartobind® Q pico — Miniaturized scaleable format for process developers
en 670.2 kB

Brochure

Sartobind® Membrane Adsorbers — Chromatography as easy as filtration
en 3.7 MB

Datasheet

Sartobind® pico 0.08 mL — Membrane chromatography tool for process development
en 231.9 kB

Flyer

Sartobind® selection guide
en 1.0 MB

User Manual

Manual Sartobind pico 0.08 mL
en 686.8 kB

Product properties

  • Connectors
    Luer female connectors
  • Primary Product Type
    Membranes
  • Type
    Membrane adsorber
  • Design
    Conventional filter design
  • Filter Format
    Capsules
  • Pore Size Final-filter
    3 – 5 µm
  • Membrane Material
    Stabilised reinforced cellulose
  • Membrane
    Strong anion exchanger
  • Membrane Area
    2.9 cm²
  • Pack Size
    10
  • Bed Volume
    0.08 mL
  • Bed Height
    4 mm

Technical attributes

  • Thermal Stability
    Sartobind capsules with ion exchange membranes can be autoclaved at 121 °C for 30 min. We recommend one autoclaving cycle only.
  • Ligand Density
    2 – 5 µeq/cm²
  • Maximum Venting Pressure
    0.5 bar, 0.05 MPa, 7 psi
  • Chemical Compatibility
    Stable in common chromatography buffers, unstable to peroxide and other oxidizing or reactive reagents
  • Reference Protein
    Bovine serum albumin
  • Application
    • Polishing
    • Screening
  • pH Stability
    pH 2 – 14 (short term)
  • Maximum Pressure
    0.6 MPa
  • Reusable
    No
  • What you receive
    • 10 units
    • 2 adapters Luer male to UNF 10-32 female
    • 1 operating instruction
    • 1 certificate
  • Materials of Construction
    Polypropylene, polyester
  • Housing Material
    Polypropylene (PP)
  • Ligand
    Quaternary ammonium
  • Membrane Type
    Strong anion exchange membrane
  • Sterilization Method
    Autoclavable
  • Dimensions (W×D×H)
    31 × 11 cm
  • Typical Dynamic Binding Capacity 10% per unit
    2.3 mg
  • Void Volume
    0.4 mL
  • Recommended Flow Rate
    0.8 – 2.4 mL/min

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