Process Chromatography Solutions
Chromatography is the workhorse of downstream bioprocesses, but capture chromatography is one of the most expensive and rate-limiting steps. Low flow rates extend the processing time and limit the productivity of downstream production. Non-value-added activities – such as column packing and system cleaning – also strain resources and increase risk, operational area, and footprint.
These chromatography challenges create broad opportunities for improving efficiency during downstream processes. It is time for the industry to collectively re-imagine chromatography to overcome these obstacles.
Imagine Being Ahead of the Curve
Re-Imagine Chromatography
The industry is on the cusp of a paradigm shift in chromatography. By embracing more effective technologies and adopting process intensification strategies, you can pioneer these innovations and establish next-generation, streamlined purification processes.
Explore our range of systems specifically designed for intensification and chromatography media to start building an efficient downstream process tailored to your needs.
Downstream process intensification increases productivity and flexibility while decreasing COGs and timelines. Yet, knowing how to integrate strategies into your process can pose a challenge.
Whether you want to boost the productivity of your capture step or intensify your entire downstream process. Find a system suitable for your purification needs.
Next-generation therapies typically rely on large particles such as nucleic acids, viral particles, and exosomes. These biomolecules challenge conventional chromatography techniques, which struggle to quickly yield high recoveries while also maintaining the required purity.
Adapt to the challenges of evolving therapeutics with next-generation solutions designed for the purification of large biomolecules.
Sartobind® Membrane Toolbox
Purify With Sartobind®
Are you ready to re-imagine your chromatography workflow? Membranes have an open structure that supports faster flow rates, accelerating process timelines and lowering the cost of goods.
Sartobind® Rapid A has several benefits compared to Protein A resins:
- Up to 14x more productivity at capture using rapid cycling
- No column-packing required, freeing up resources
- Lifetime utilization is achieved in one batch, minimizing storage requirements
Our broader Sartobind® Membrane toolbox covers the entire workflow and offers up to 30x productivity gain during polishing in flowthrough mode.
Resolute® BioSMB
Intensify with Resolute® BioSMB
Are you ready to re-imagine your chromatography workflow? Multi-column chromatography supports better resin utilization, meaning considerable savings, especially at the affinity capture step.
Intensify your capture chromatography with the Resolute® BioSMB multi-column chromatography system:
- Up to 80% reduction in resin volumes and costs
- Up to 5x increase in productivity
- Reduced buffer consumption
Resolute® BioSC
Intensify with Resolute® BioSC
Are you ready to re-imagine your entire downstream process? Our multi-step chromatography solutions support the connected and continuous operation of multiple steps on a single system.
Intensify your downstream workflow with the Resolute® BioSC multi-step chromatography system.
- Up to 3x reduction in footprint
- Reduced CAPEX
- Up to 40% reduction in batch time
- Modular concept means you can configure the system to fit your process needs
CIM® Monoliths
Purify Nucleic Acids or Viral Vectors With Monoliths
Are you ready to re-imagine large biomolecule purification? Our chromatography monoliths are ideal for the purification of molecules commonly used in next-generation therapies (such as mRNA and viral particles).
Enhance the purification of your new modalities with CIM® monolithic chromatography.
- High-resolution capabilities in combination with low shear flow properties for quality yields
- Increased productivity thanks to improved yields and faster run times
- Available in plug-and-play formats across a large range of chemistries and scales
Explore Our Wider Chromatography Portfolio
Learn More About Process Chromatography
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