Resolute® BioSMB Platform
Single-Use Multi-Column Chromatography from Process Development to Manufacturing
Process intensification is an optimal solution to address chromatography challenges, providing substantial improvements to productivity, cost, timelines, and facility footprint. Our flexible portfolio lets you choose an intensification strategy that aligns with your unique process goals.
Multi-column chromatography supports better resin utilization, meaning more product is bound in less time and at a reduced cost. The Resolute® BioSMB is the perfect solution for those seeking lower production costs and limit resin usage with minimal disruption to current chromatography methods.
Improved resin utilization and reduced resin quantities, decreasing overall manufacturing costs
Up to 2x reduction in buffer volumes, improving sustainability
Uses the same valve technology, recipes, and flowpath configuration for process development and manufacturing systems, streamlining scale-up
Resolute® BioSMB Platform for Both Batch and Continuous Processes
Resolute® BioSMB platform is a family of chromatography systems designed to purify biologics from process development to commercial manufacturing scale. Resolute® BioSMB is versatile and can be deployed as part of a traditional batch process or a continuous downstream process.
| Resolute® BioSMB PD | Resolute® BioSMB 80 | Resolute® BioSMB 350 | |
|---|---|---|---|
Scale | Process Development | Clinical | Commercial Manufacturing | Clinical | Commercial Manufacturing |
Number of Column Positions | 1 to 16 | 1 to 8 | 1 to 8 |
Flow Rate Range | 1 mm cassette: up to 50 mL/min | 5-80 L/hr (83-1300 mL/min) | 30-350 L/hr (500– 5800 mL/min) |
Application | Process development | Typically for perfusion-based or smaller processes up to 500 L bioreactor | Typically for larger processes up to 2000 L bioreactor |
Learn More About Resolute® BioSMB Systems
Virtual Demo of the Resolute® BioSMB PD System
To learn about the ease of installation, set-up, and main features of the Resolute® BioSMB PD system, watch this video.
Virtual Demo of the Resolute® BioSMB 80 | 350 System
To learn how the Resolute® BioSMB platform can be easily scaled up from early-stage process development through clinical manufacture and beyond, watch this video.
Simplify the Management and Analysis of Resolute® BioSMB PD Data
With our Resolute® BioSMB Data Analysis and Reporting software, users can speed up processing large volumes of Resolute® BioSMB PD data utilizing a user-friendly interface. This software is designed to:
- Perform a wide range of chromatography calculations on both peaks and transitions
- View and analyze historical Resolute® BioSMB PD results rapidly
- Visualize Resolute® BioSMB PD data from multiple cycles or runs
Traditional Batch vs Multi-Column Chromatography
Continuous Multi-Column Chromatography: Better Than Batch Chromatography
In traditional single-column batch chromatography, there are inherent limitations because the system rarely uses the full capacity of the stationary phase during loading. In multi-column chromatography, the large column is split into a number of smaller columns that can be processed individually, eliminating idle zones. In addition, the flexible valve configuration allows breakthrough of the product stream to a secondary column, which allows the full capacity of the column to be used through overloading, leading to improved process efficiency with increased resin capacity utilization.
How to Debottleneck Downstream using Multi-Column Chromatography
Making the switch from single batch to multi-column chromatography can dramatically reduce resin volumes, reducing costs and eliminating bottlenecks without sacrificing quality. This animated feature compares the traditional, single column batch approach to a multi-column alternative for mAb capture.
Featured Assets
Articles, Application Notes & White Papers
Re-Imagining Chromatography - Building Efficient, Connected Downstream Processes
PDF | 2.4 MB
Merck Process Transfer and Scale-Up of Batch Protein A Chromatography to Resolute® BioSMB Multi-Column Platform
PDF | 577.3 KB
