BioSMB PD - Multi-Column Chromatography for Early-Stage Process Development

The BioSMB PD system is a multi-column chromatography (MCC) solution sized for lab-scale process development. Unlike batch chromatographic processing, which relies on a single large column, the BioSMB PD system can process from 1 to 16 columns.  

The use of MCC leads to increased productivity and  a consequent significant reduction in chromatographic resin use.

Reduce utilization of chromatographic resins

Inherent unit operation efficiency of the system reduces resin costs by up to 80% without changing either the separation media or buffer used.

Increase application flexibility

Availability of 16 column positions can support a range of capture and polishing steps, such as in HIC, SEC and mixed-mode chromatography.

Scale up and down

Valve technology, flow path configuration and recipe handling consistent between benchtop and GMP scale systems to ensure scalability.

Reduce cleaning and sanitation costs

Disposable valve cassette designed as a single-use component, eliminating the need for difficult cleaning validation processes.

Reduce footprint of unit operations

Eliminate the need for packing skids, large stainless-steel columns and other support infrastructure .

Selecting The Right Technology for Your Process : Batch vs Continuous

As the industry moves toward process intensification and continuous processing, the BioSMB platform provides an ideal opportunity to start exploring possible starting points. For customers seeking lower production costs with a single-use solution for clinical and commercial processing, BioSMB can reduce resin usage by up to 80% with minimal disruption to the accepted ways of doing chromatography today. This presents a considerable saving on operational expenditure, particularly when considering affinity capture steps.   

For users who are actively evaluating perfusion, BioSMB delivers a viable entry point and scale-up pathway. 

The BioSMB platform provides:

  • A highly flexible multicolumn chromatography system
  • High throughput and very efficient resin utilization
  • An open platform that enables the use of many chromatography technologies
  • A fully scalable solution for applications ranging from early-stage process development through clinical manufacture and beyond 

Request a Demo

Designed for Performance and Productivity

Because the BioSMB PD system contains 16 smaller columns, it overcomes many limitations of larger, single-column batch systems. The first column in the load zone is allowed to reach breakthrough, and product breakthrough is captured on a second column. As a result, the binding capacity of the first column far exceeds its batch dynamic binding capacity. In many cases, processes can be operated close to the equilibrium or static binding capacity of the resins, leading to a significant reduction in overall resin usage.

The BioSMB PD system:

  •  Uses only a fraction of the chromatography resin used in a standard batch process
  •  Offers a smaller overall footprint and more scalable configuration
  •  Accommodates production titers greater than 5 g/L
  •  Automates a wide variety of separation modes, including bind/elute mode and flowthrough mode

Request a Demo

System Details

General Specifications



Width / Depth / Height

120 / 73 / 58 cm
(47.2 / 28.7 / 22.8 in.)


170 kg
(375 lbs)

Electrical Requirements

115 V or 230 V

Required Air Supply

At least 1 barg (14.5 psig) above process pressure

System and Valve Cassette Specifications



Flow Rate Range

1 mm cassette: Up to 50 mL/min
3 mm cassette: Up to 100 mL/min


Maximum 8 (including loopback)


Maximum 6 (including loopback)


Maximum 16

Maximum Operating Pressure

10 barg (145 psig)

Sensor Specifications




Linear up to 13.8 barg (200 psig)

Ultraviolet-Visible (UV-VIS)

Four UV-VIS sensors each with wavelengths in 210-850 nm range


Maximum 8 Range of 0-14, accuracy of 0.1 pH unit (from 2 to 12)


Range: 1 μS/cm – 200 mS/cm
Accuracy: 0.25 mS/cm (range 10 – 200 mS/cm) 3.0 μS/cm (range 0 – 100 μS/cm)

Pump Specifications

Maximum of 7 pumps
Stepper motor belt drive dual piston pumps, PEEK fluid path, automated piston seal wash, double capsule check valve with additional anti-siphoning valve


0.5 - 50 mL/min ± 5% (with 1 mm cassette)
0.5 - 100 mL/min ± 5% (with 3 mm cassette)

Part Number



BioSMB PD 1 mm Process Development System


BioSMB PD 1 mm Process Development Valve Cassette only


BioSMB PD 3 mm Process Development Valve Cassette only

Request a Quote

Simplify the Management and Analysis of BioSMB PD Data

With our BioSMB Data Analysis and Reporting software, users can speed up processing large volumes of BioSMB PD data in a user-friendly interface. This software is designed to:

  • Perform a wide range of chromatography calculations on both peaks and transitions
  • View and Analyze historical BioSMB PD results rapidly
  • Visualize BioSMB PD data from multiple cycles or runs

Download Datasheet

Learn More About the BioSMB PD System

Virtual Demo of the BioSMB PD System

The BioSMB platform is a scalable solution for applications ranging from early-stage process development through clinical manufacture and be...

Watch Webinar Online

Meet the New Generation of Celsius® FFT and FFTp | August 31

Webinar explores expertise and experimentation behind the new generation of Celsius® FFT products

Register Now


Increase Throughput 6X with Multi-Column Chromatography

Explore how BioSMB multi-column chromatography overcomes the limitations of batch chromatography and leads to sixfold gains in throughput. 

Watch Now

Featured Case Study

Protein A Resin Reduction Achieved With Process Transfer From Batch to BioSMB

Sanofi wanted to upgrade from an existing batch chromatography process to the BioSMB multi-column format, then scale up that process to a continuous perfusion run. This case study details the real-world results.

Download Case Study

Related Assets


BioSMB PD System

PDF | 894.2 KB

BioSMB Data Analysis and Reporting Software

PDF | 5.7 MB
Success Story

BioSMB Increased Productivity at mAB Capture Step

PDF | 230.4 KB

In with the New: Embracing Multicolumn Chromatography

PDF | 595.7 KB

Consult Our Experts

Consult Our Experts

Related Products

BioSMB Process 80/350

Learn more about single-use, multi-column chromatography designed exclusively for clinical- and commercial-scale manufacturing under GMP.

Learn More

Multi-Use Batch Systems

Read how fully automated chromatography systems with proven scalability can reduce process costs for large-scale manufacturing.

Learn More

Single-Use Batch Systems

Single-use systems, such as our Standard Resolute®️ Flowdrive SU chromatography platform, can lead to significant cost savings.

Learn More