White Paper: Understanding T Cell Phenotype and Function to Enable Improved Therapeutics
T cells play a vital role in pathogen elimination and tumor immunosurveillance. The human body is capable of producing an array of specialized T cells that provide unique responses to the diverse spectrum of tumor cells and pathogens (viruses, bacteria and parasites) that are capable of penetrating host defenses.
The modulation of T cells is an exciting prospect for the development of novel therapies for immuno-oncology –autoimmune applications, adoptive cell therapy and vaccine development.
This white paper provides an overview of the importance of understanding T Cell Biology to build better therapeutics and the use of advanced flow cytometry to study the processes controlling T cell activation, killing and exhaustion using 3 case studies as examples.
- Patient to Patient Variability
- BiTE antibody evaluation
- CAR-T cell characterization