The Fundamentals of Viral Vector Downstream Processing (VV-DSP)
Guided Learning at Your Own Pace with Experts
This course will provide you with the necessary scientific background on viral vectors, strengthening your understanding about different methods used for viral vector purification (chromatography, filtration, etc.) and analytics, along with the overview on market for viral vectors
It includes:
- Mix of self-paced and instructional units with 4 - 5 hours of learning per week (45 – 50 hours in total) over 3 months.
- Interactive collaborative platform to facilitate knowledge exchange
- Limited synchronous activities allow participation from across the globe
- 99% recommendation rate from previous learners
Duration:
45 - 50 h
Self-Learning Program Available From:
Registration is open. Register your interest by filling out the form at the bottom of this page.
Lab managers, team leads, researchers, engineers and scientists with expertise in bioprocessing and basic knowledge of gene therapy. Fluent English is essential for optimal learning.
Upon completion of this course, you will be able to Strengthen the understanding about different methods used for viral vector purification including general process and workflow, purification strategies, analytics, sterility and bioburden. It will also offer insight into the market and trends as well as industry needs and challenges.
This online course consists of both self-paced and collaborative learning units, allowing you to fit in learning around your work schedule. Each chapter includes live discussions, assignments, access to experts and Q&A sessions, using an interactive and collaborative platform to facilitate knowledge exchange between participants.
Focus Topics & Agenda
How is the Sartorius Academy’s Fundamentals of Viral Vector Downstream Processing course structured?
Kickoff |
Chapter 1: Pre-learning |
Chapter 2: Clarification |
Chapter 3: Concentration & Diafiltration |
Chapter 4: Capture & Polishing |
Chapter 5: Filtration & Closed Processes |
Chapter 6: Analytics |
Wrap-up |
Learning Modules
Duration: 1.5 weeks
- Get an understanding of the viral vector market, the main vectors and their applications
- Understand the physical properties of viruses
- Review the Upstream Workflow for Viral vector production
- Get an overview of contaminants and impurities that need to be removed during the DSP
Duration: 1.5 weeks
- Review of the existing technologies for clarification of viral vectors, their advantages and limitations
- Guidelines to select the right technologies for clarification of AAV, LV and ADV
- Scale-up considerations
Duration: 1.5 weeks
- Review of technologies adapted to ultrafiltration and diafiltration of viral vectors
- Common sources of failures
- Recommendations for concentration of shear sensitive enveloped vectors
- Scale-up considerations
Duration: 2.0 weeks
- Overview of chromatography solutions for purification of AAV, LV and ADV
- Guidelines for process optimization
- Common sources of failures
- Scale-up considerations
Duration: 1.0 weeks
- Overview of solutions for sterile filtration and bioburden reduction
- Case studies for LV, AAV, ADV
- Understand how to implement closed processing
- Get an insight about viral filtration
- Scale-up considerations
Duration: 1.5 weeks
- Get an understanding of what needs to be monitored during the DSP of viral vectors, and why
- Review of the technologies used for viral vector and contaminant quantifications
- Get an understanding of the advantages of each technology, and how they can be selected
