Cubis®️ II Loss on Drying

Application Highlight

Loss on Drying is a back-weighing application to determine the amount of volatile matter in tablets, capsules, or bulky material. Samples are weighed before and after treatment, and the weight difference is measured. According to the US Pharmacopoeia Chapter 731 (USP Chapter 731) 1–2 g of sample is mixed; for large particles the size is reduced to about 2 mm by quickly crushing. If tablets are to be tested, the powder of not less than 4 tablets must be used; For capsules, the mixed contents of not less than 4 capsules must be used.

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