High-throughput Solutions that Empower Research & Discovery
May 11 – 15, 2023 | Washington, DC
Walter E. Washington Convention Center
Booth #6072
Explore the latest developments in immunology research and discuss your next breakthrough therapeutic with Sartorius experts at IMMUNOLOGY2023™. Stop by booth #6072 to learn more about our innovative platforms and products:
- The iQue® Advanced Flow Cytometry Platform utilizes a fixed wide dynamic range allowing for the simultaneous collection of both the phenotypes and functional analysis of secreted cytokines, eliminating the discrepancy of different time points or the need to split samples for subsequent analysis.
- Incucyte® Live-Cell Analysis Platforms are designed to efficiently capture cellular changes where they happen - in the incubator. Capture high-resolution fluorescence and bright field images and record data in real time over hours, days or weeks. From proliferation assays to immune killing of tumor spheroids, these flexible systems enable users to observe and quantify complex biological changes in real time.
- The Octet® Platform is a comprehensive solution for screening and characterizing molecular interactions such as protein-protein or protein-drug, enabling an enviable assortment of applications throughout biologics development from early selection to validation to manufacturing.
Can’t make it to the show? Please fill out the form below to request information and a specialist will be in touch shortly.
Please join us for our presentations:
Friday, May 12 from 2:30-3:45pm: Multi-Parametric Quantification of Monocytes Using Live-Cell Analysis
Monocytes play critical roles in innate immunity by migrating to inflamed tissue, where they clear micro-organisms and apoptotic cells, repair injured tissues, and recruit other immune cells. This presentation will provide robust in vitro assays, using live-cell imaging and advanced flow cytometry, for the kinetic evaluation of monocytes and demonstrate how these further our understanding of their biological roles.
Saturday, May 13 from 2:30-3:45pm: Quantifying in Vitro Complement-Dependent Cytotoxicity (CDC) Using Advanced Flow Cytometry
We will present a streamlined assay for measuring complement-dependent cytotoxicity CDC using the iQue®️ Advanced Flow Cytometry Platform.
Target cells are cultured with monoclonal antibodies (mAbs) of interest and human serum, then labeled using iQue®️ Cell Membrane Integrity (R/Red) Dye to quantify cell death. Combining the high-throughput of the iQue®️ with rapid data analysis using the integrated iQue Forecyt®️ software streamlines antibody characterization and drug discovery processes.
Sunday, May 14 from 10:00-10:45am: Comparing Tumor Killing Mechanisms of Antibody Drug Conjugates (ADC’s) with the iQue® Flow Cytometry system
Presented by Kirsty Mcbain | Scientist and Don Weldon | Cell Analysis Technology Expert
Antibody drug conjugates (ADCs) marry together two types of cancer treatment, chemotherapy and immunotherapy, to create highly specific and efficacious therapeutics. Each ADC has been designed with unique features such as the position, number and identity of the cytotoxic payload, as well as the structure of the adjoining linker. These characteristics mean that even ADCs based on the same monoclonal antibody backbone can have largely different functional profiles. Here, we describe the use of the iQue® Flow Cytometry Platform to profile the binding and tumor cell killing mechanism of anti-HER2 ADCs.
