Translate Insights into Novel Strategies for Viral Vaccine Research

Groundbreaking Technologies and Associated Services to Enable Researcher to Accelerate and Advance Discovery and Development of Viral Vaccines & Vectors

Although a great deal of progress has been made in vaccine research, recent headlines remind us that we still have much to do to advance and accelerate the discovery process.

The recent global outbreak of coronavirus diseases (COVID-19) caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) serves as a stark reminder of the imminent threat of unexpected pathogens. We need a deeper understanding of the cellular and molecular mechanisms that drive immune responses against emerging infectious diseases (EIDs). See how Sartorius' innovative,  groundbreaking solutions advance and accelerate your discovery and development of new vaccines against viral infections.
 

  • Cell & Protein Analysis Platforms - For tracking complex host - pathogen biological processes, you need high-capacity cell analysis solutions to generate deeper, more relevant data on phenotype, activation, and function.
  • Cell Culture and Downstream Applications - For progressing with your leads rapidly through the pipeline you need high throughput, multi-parallel cell culture systems and streamlined downstream applications.

Expediting Next-Generation Vaccine Development Using Advanced Analytical Methods

Expediting Next-Generation Vaccine Development

Using Advanced Analytical Methods. Article taken from European Biopharmaceutical Review April 2021

Read Article
infographic thumbnail

Developing Viral Vaccines for Infectious Diseases

Learn about innovative technologies that support and accelerate vaccine discovery to help combat new and emerging pathogens

Download Infographic
Virology/Viral Immunology eBook

New Research and Development Strategies in Virology/Viral Immunology

Learn about the latest studies highlighting novel strategies and methodologies to accelerate vaccine development to combat infectious disease.

Download eBook
viral vaccine research brochure

Sartorius Solutions for Viral Vaccine Research

Download Brochure

Cell Analysis Tools to Accelerate and Advance Vaccine Research

iQue®️ Advanced Flow Cytometry Platform

Advanced flow cytometry platform to get from samples to actionable results in record time.

The iQue® Advanced Flow Cytometry Platform can be used for viral research activities such as monitoring host-pathogen interactions, antibody library screening, immune response assessment, epitope mapping, and antibody neutralization studies.

Discover iQue®

Incucyte® Live-Cell Analysis System 

In the race for a vaccine, accelerating biological insight is critical.

The Incucyte® Live-Cell Analysis System improves productivity with powerful, automated image acquisition. Accelerate your next discovery with a flexible assay platform that accommodates multiple applications simultaneously with multi-plate throughput. Protect your cells and your team, by performing analysis with networked, remote access as your cells remain in the physiologically relevant environment of the incubator. 

With automated analysis and a portfolio of reagents, consumables and software specifically designed to detect dynamic immune response, solving biologically relevant questions has never been easier!

Discover Incucyte®

Cell Analysis Featured COVID Research

Antibody Neutralization
Neutralizing antibodies have the potential of therapeutic agents.
See how a potently neutralizing human monoclonal antibody with post-exposure therapeutic activity against ZIKV infection was developed in a mouse model. - Read more by Long et al. PNAS, 2019

Viral Therapeutics and Vaccine Development
Development of an influenza virus pseudo typed with Ebolavirus glycoprotein to aid therapeutic screening. - Read more by Xiao JH et al.  J Virol. 2018 Jan 30;92(4)

View our complete list of publications

Explore Consumables

Target Identification

Delve Deeper Into the Biology of T Cell Exhaustion With Our New Human T Cell Exhaustion Cell and Cytokine Profiling Kit

Explore Profiling Kits

Virology Assays

Explore the Entire Host-Pathogen Life Cycle with Advanced Cell Analysis Solutions.

Discover Virology Assays

Applications for Cell Analysis

T Cell Characterization

Gaining deeper insights into therapeutic development with in-depth T Cell Characterization.

Learn More

Cytotoxicity

Detect real-time measurements of cell death based on cell membrane integrity.

Learn More

Apoptosis

Investigate aberrations in apoptotic pathways in intact, living cells.

Learn More

Immune Cell Clustering and Proliferation

Understand the mechanisms of immune cell activation, proliferation and regulation.

Learn More

iQue® Advanced Flow Cytometry Platform

Advanced flow cytometry platform to get from samples to actionable results in record time. Evaluate cytotoxicity, apoptosis and other biological...

Learn More

Viral Replication and Infection Assays

Viral replication and infection assays enable the study of pathogenesis in host cultures and the testing of novel antiviral therapeutics.

Learn more

Reporter Genes

Measure signalling pathway activation and activity of promoter driven reporter gene expression in real time.

Learn More

Immune Cell Killing

Real time visualization and fully automated analysis of tumor cell killing.

Learn More

All-in-One Octet® Platforms

Octet® Label-Free Bio-Layer Interferometry (BLI) Detection Systems

The Octet® Bio-Layer Interferometry (BLI) platform offers unprecedented time and cost savings during biomolecular interactions analysis.  Octet systems accelerate COVID-19 research, and will help you to:

  • Select vaccine and therapeutics candidates faster
  • Categorize antibodies into epitope bins efficiently
  • Simplify workflows through our wide variety of available biosensors
  • Facilitate titer, potency and stability measurements in upstream and downstream vaccine and biotherapeutics development and manufacturing 
  • Analyze data with intuitive easy-to-use software tools

Explore Octet® Systems

Octet® Featured COVID Research

Analysis of coronavirus binding to host receptors
Affinity and kinetics of virus-host receptor binding interactions are crucial to understanding viral pathogenesis and therapeutic development approaches. Octet platforms enable fast and accurate analysis of binding interactions in real-time. - Read More by Walls et al. Cell, 2020

View our complete list of publications on coronavirus research

Infographic

Understanding COVID-19 Vaccine and Therapeutic Development Research

Studying antibodies from COVID-19 infections and vaccines can provide invaluable information toward therapeutic antibody development

Download Infographic

Tools for Your Downstream Vaccine Research

Clarification and Filtration

Sartoclear Dynamics® Lab V50 kits: Virus harvesting in one step
Kits combining a vacuum filtration unit, Sartolab® RF 50 with a 0.45 µm PES membrane and a filter aid for clarification.

Explore Filtration Kits Download Brochure

Concentration and Purification of Viruses

Vivapure® Virus Purification and Concentration Kits
Adenovirus and lentivirus purification kits utilize membrane adsorber technology for fast and safe virus purification.

Explore More

Application Note: Ultrafiltration Methods for the Concentration and Purification of Viruses

Concentration, Purification  and Diafiltration of proteins (antigens and antibodies)

Vivaflow®, Vivaspin® and Vivapure® Ultrafilters
Perfect solutions for your ultrafiltration needs serving the complete protein ultrafiltration workflow: From concentration and diafiltration of the original protein source, a cell culture supernatant, to final concentration.

Explore More

Centrisart® Centrifuges

The Centrisart® Centrifuge Family portfolio ranges from very compact and space-saving micro-centrifuges to universally applicable benchtop centrifuges with a total capacity of up to 1,600 mL. Perfect for nucleic acid isolation for PCR testing.

Explore Centrifuges

Picus Electronic and Tacta Mechanical Pipettes

Ergonomics – Pipetting for Your Safety
A basic but repetitive application, therefore ergonomics is key.

Discover Pipetting Solutions

Pipette Controllers and Bottle-top Dispensers

Do you need to dispense large volumes straight from a bottle or tube?
To make it easy for you, we offer handy pipette controllers and bottle-top dispensers.

Discover Dispensing Solutions

Titer, Potency and Stability Measurements

Octet® quantitation assays are perfect solutions to measure antibody and vaccine titers in your process development samples that provides fast at-line testing capabilities. With a variety of ready-to-use quantitation specific biosensors, a  full 96-plate of antibody or vaccine titers can be measured within minutes using the octet.

Discover Titer Impurity Testing

See how Vivaspin® ultrafilter was used in recent Coronavirus related research experiments for concentration of Virus Like Particles (VLPs) and proteins.

                                               
Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response. Glowacka et al. Journal of Virology - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126222/

Expression, purification and crystallization of the SARS-CoV macro domain. Malet et al. Crystallography Journals Online - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222557/

Structure of the SARS-Unique Domain C From the Bat Coronavirus HKU4. Staup et al. SAGE Journals - https://journals.sagepub.com/doi/full/10.1177/1934578X19849202

Structure, Function, and Antigenicity of the SARSCoV-2 Spike Glycoprotein. Walls et al. Cell
- https://doi.org/10.1016/j.cell.2020.02.058  

Cubis®️ II Modular Premium Laboratory Balances

Cubis®️ II for Vaccine Development

Sample weighing is a commonly occurring step during vaccine research and development, and in pre-clinical phases where the most reliable lab weighing results have the utmost importance. As vaccine research becomes more challenging with the continuous emergence of new diseases and novel safety concerns, higher standards of precision, as well as flexibility and speed, are necessitated during these workflows.

Explore Cubis® II Download Brochure

Precision, Simplicity, Intuitive Operation

Cubis®️ II laboratory balances offer customizable hardware and software, modern user interfaces, pharmaceutical and GxP compliance, including data integrity at the highest level of accuracy and precision. With our broad spectrum of solutions and long term expertise, we guarantee the highest level of accuracy, and also support your weighing workflows in a simplified and intuitive manner.

  • Highest Level of Precision
  • Simplified Weighing Processes
  • Intuitive Workflows
  • Customized Solutions

Read App Highlight

Additional Products

Microsart® AMP Mycoplasma Kit

Ensure your results are from your cells, not contamination. Screen your cultures with our real-time PCR kit for mycoplasma contamination.

Buy Now

Microsart® RESEARCH Bacteria

Provides rapid detection of total bacteria within 2½ h. For fast and reliable real-time PCR-based detection of bacterial contamination in cell...

Buy Now

Mycap® CCX Cell Expansion System

Reliable aseptic technique for cell culture expansion. A revolutionary closed design that ensures media feed, inoculation, sampling, and...

Explore More

Arium® Ultrapure Water Systems

Designed for efficient removal of endotoxins, RNase, DNase, microorganisms and particles. Provides the highest safety for your critical cell...

Explore More

Claristep® Filtration System

The manually operated Claristep® Filtration System consisting of a station and filter units provides a modern, simple fix for HPLCs demanding needs.

Explore More

Blotting Papers

Soak it up right! Pure blotting paper and consistent CN membrane for reproducible results.

Explore More
Contact an Expert

Visit a Location Near You

Expand Your Knowledge with a Process-Specific Consultation on Your Production Process

Sartorius Application Centers are located in Germany, China and the United States. It is your opportunity to experience Sartorius solutions for your specific bioprocess as well as laboratory tasks and applications. By meeting our industry experts you will receive a highly process- and application-specific consultation alongside hands-on tests of our cutting-edge technology.

  • Learn about market trends and how they will affect your industry
  • Experience flexible, reliable and smart equipment for your applications See which combination of equipment fit best for your current process and beyond Find out how safe and easy it is to work with single-use systems and consumables
  • Discover our customized solutions and services for your specific needs
  • Communicate and exchange know-how with our industry experts!

Visit Application Center

Further Your Vaccine Manufacturing Process

Vaccine Manufacturing, Process Development and Production

Explore More

Cell Line and Media Testing Solutions

Explore More

Request More Information

What other areas are you interested in? (select all that apply)