Translate Insights into Novel Strategies for Viral Vaccine Research
Groundbreaking Technologies and Associated Services to Enable Researcher to Accelerate and Advance Discovery and Development of Viral Vaccines & Vectors
Although a great deal of progress has been made in vaccine research, recent headlines remind us that we still have much to do to advance and accelerate the discovery process.
The recent global outbreak of coronavirus diseases (COVID-19) caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) serves as a stark reminder of the imminent threat of unexpected pathogens. We need a deeper understanding of the cellular and molecular mechanisms that drive immune responses against emerging infectious diseases (EIDs). See how Sartorius' innovative, groundbreaking solutions advance and accelerate your discovery and development of new vaccines against viral infections.
- Cell & Protein Analysis Platforms - For tracking complex host - pathogen biological processes, you need high-capacity cell analysis solutions to generate deeper, more relevant data on phenotype, activation, and function.
- Cell Culture and Downstream Applications - For progressing with your leads rapidly through the pipeline you need high throughput, multi-parallel cell culture systems and streamlined downstream applications.
Cell Analysis Tools to Accelerate and Advance Vaccine Research
iQue®️ Advanced Flow Cytometry Platform
Advanced flow cytometry platform to get from samples to actionable results in record time.
The iQue® Advanced Flow Cytometry Platform can be used for viral research activities such as monitoring host-pathogen interactions, antibody library screening, immune response assessment, epitope mapping, and antibody neutralization studies.
Incucyte® Live-Cell Analysis System
In the race for a vaccine, accelerating biological insight is critical.
The Incucyte® Live-Cell Analysis System improves productivity with powerful, automated image acquisition. Accelerate your next discovery with a flexible assay platform that accommodates multiple applications simultaneously with multi-plate throughput. Protect your cells and your team, by performing analysis with networked, remote access as your cells remain in the physiologically relevant environment of the incubator.
With automated analysis and a portfolio of reagents, consumables and software specifically designed to detect dynamic immune response, solving biologically relevant questions has never been easier!
Cell Analysis Featured COVID Research
Neutralizing antibodies have the potential of therapeutic agents.
See how a potently neutralizing human monoclonal antibody with post-exposure therapeutic activity against ZIKV infection was developed in a mouse model. - Read more by Long et al. PNAS, 2019
Viral Therapeutics and Vaccine Development
Development of an influenza virus pseudo typed with Ebolavirus glycoprotein to aid therapeutic screening. - Read more by Xiao JH et al. J Virol. 2018 Jan 30;92(4)
Applications for Cell Analysis
All-in-One Octet® Platforms
Octet® Label-Free Bio-Layer Interferometry (BLI) Detection Systems
The Octet® Bio-Layer Interferometry (BLI) platform offers unprecedented time and cost savings during biomolecular interactions analysis. Octet systems accelerate COVID-19 research, and will help you to:
- Select vaccine and therapeutics candidates faster
- Categorize antibodies into epitope bins efficiently
- Simplify workflows through our wide variety of available biosensors
- Facilitate titer, potency and stability measurements in upstream and downstream vaccine and biotherapeutics development and manufacturing
- Analyze data with intuitive easy-to-use software tools
Octet® Featured COVID Research
Analysis of coronavirus binding to host receptors
Affinity and kinetics of virus-host receptor binding interactions are crucial to understanding viral pathogenesis and therapeutic development approaches. Octet platforms enable fast and accurate analysis of binding interactions in real-time. - Read More by Walls et al. Cell, 2020
Tools for Your Downstream Vaccine Research
Concentration and Purification of Viruses
Vivapure® Virus Purification and Concentration Kits
Adenovirus and lentivirus purification kits utilize membrane adsorber technology for fast and safe virus purification.
Concentration, Purification and Diafiltration of proteins (antigens and antibodies)
Vivaflow®, Vivaspin® and Vivapure® Ultrafilters
Perfect solutions for your ultrafiltration needs serving the complete protein ultrafiltration workflow: From concentration and diafiltration of the original protein source, a cell culture supernatant, to final concentration.
The Centrisart® Centrifuge Family portfolio ranges from very compact and space-saving micro-centrifuges to universally applicable benchtop centrifuges with a total capacity of up to 1,600 mL. Perfect for nucleic acid isolation for PCR testing.
Picus Electronic and Tacta Mechanical Pipettes
Ergonomics – Pipetting for Your Safety
A basic but repetitive application, therefore ergonomics is key.
Pipette Controllers and Bottle-top Dispensers
Do you need to dispense large volumes straight from a bottle or tube?
To make it easy for you, we offer handy pipette controllers and bottle-top dispensers.
Titer, Potency and Stability Measurements
Octet® quantitation assays are perfect solutions to measure antibody and vaccine titers in your process development samples that provides fast at-line testing capabilities. With a variety of ready-to-use quantitation specific biosensors, a full 96-plate of antibody or vaccine titers can be measured within minutes using the octet.
See how Vivaspin® ultrafilter was used in recent Coronavirus related research experiments for concentration of Virus Like Particles (VLPs) and proteins.
Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response. Glowacka et al. Journal of Virology - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126222/
Expression, purification and crystallization of the SARS-CoV macro domain. Malet et al. Crystallography Journals Online - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222557/
Structure of the SARS-Unique Domain C From the Bat Coronavirus HKU4. Staup et al. SAGE Journals - https://journals.sagepub.com/doi/full/10.1177/1934578X19849202
Structure, Function, and Antigenicity of the SARSCoV-2 Spike Glycoprotein. Walls et al. Cell
Cubis®️ II Modular Premium Laboratory Balances
Cubis®️ II for Vaccine Development
Sample weighing is a commonly occurring step during vaccine research and development, and in pre-clinical phases where the most reliable lab weighing results have the utmost importance. As vaccine research becomes more challenging with the continuous emergence of new diseases and novel safety concerns, higher standards of precision, as well as flexibility and speed, are necessitated during these workflows.
Precision, Simplicity, Intuitive Operation
Cubis®️ II laboratory balances offer customizable hardware and software, modern user interfaces, pharmaceutical and GxP compliance, including data integrity at the highest level of accuracy and precision. With our broad spectrum of solutions and long term expertise, we guarantee the highest level of accuracy, and also support your weighing workflows in a simplified and intuitive manner.
- Highest Level of Precision
- Simplified Weighing Processes
- Intuitive Workflows
- Customized Solutions
Visit a Location Near You
Expand Your Knowledge with a Process-Specific Consultation on Your Production Process
Sartorius Application Centers are located in Germany, China and the United States. It is your opportunity to experience Sartorius solutions for your specific bioprocess as well as laboratory tasks and applications. By meeting our industry experts you will receive a highly process- and application-specific consultation alongside hands-on tests of our cutting-edge technology.
- Learn about market trends and how they will affect your industry
- Experience flexible, reliable and smart equipment for your applications See which combination of equipment fit best for your current process and beyond Find out how safe and easy it is to work with single-use systems and consumables
- Discover our customized solutions and services for your specific needs
- Communicate and exchange know-how with our industry experts!