Solutions to Advance Therapeutic Peptide Research
To date, over 60 peptide drugs have been approved worldwide; over 150 are in active clinical development.
Although the first native peptides such as insulin and ACTH were isolated from mammalian tissues, most native peptides currently on the market are produced synthetically or through recombinant expression. Novel development strategies are focusing on the improvement of pharmaceutical properties of native and analog peptides such as half-life extension, oral bio-availability and intestinal permeability.
Cell Analysis Platforms
By identifying new peptide drugs and small molecules that target peptide receptors high-throughput screening (HTS) and live cell analysis technologies offer unique solutions to accelerate the discovery process.
iQue® Advanced Flow Cytometry Platform
Built to Accelerate Your Research - Get from samples to actionable results in record time!
Assess multiple cellular parameters faster, with fewer cells using lower amounts of reagents. With high throughput sample processing and analysis, and the ability to simultaneously collect data on multiple parameters, the iQue Advanced Flow Cytometry platform is transforming biologics discovery by converting the low throughput, time consuming traditional flow cytometry approach into a truly advanced screening and profiling method with deeper, more efficient insight.
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Incucyte® Live-Cell Analysis System
Gain insight into the cellular effects of your peptide drug candidate, directly from inside your incubator, with our real-time quantitative live-cell imager and analyzer.
The Incucyte® Live-Cell Analysis System is a real-time quantitative live-cell imaging and analysis platform that enables visualization and quantification of cell behavior over time, by automatically gathering and analyzing images around the clock within a standard laboratory incubator. This groundbreaking technology allows researchers to make time-lapsed, kinetic measurements from living cells over days and weeks providing insight into active biological processes in real time.
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Qbeads® Plexscreen family of reagents use immunochemistry to capture specific secreted proteins on distinct bead types. We offer beads for human, mouse and rat secreted proteins.
Qbeads® Family of Reagents enable capture of specific proteins on distinct bead types for multiplexed quantitation of cytokines, adhesion molecules, enzymes, growth factors receptors and more.
Cellular Phenotype and Function Applications
Mix-and-read screening kits include optimized reagents and flexible formats validated for the iQue platform. No wash protocols save time, reduce variability and allow for miniaturization. Kits can be multiplexed to increase assay content and reduce sample requirements.
Immune Cell-Based Kits enable the analysis of multiple immunological cell phenotypes and functional traits such as viability, proliferation, and cytokine release.
White Paper: Live-Cell Immunocytochemistry
Immunocytochemistry (ICC) is a powerful laboratory imaging technique for visualizing the location of specific proteins in cells using targeted fluorescently-labeled antibodies (‘immunofluorescence’). In this article, we introduce an integrated solution for ‘live-cell’ ICC, based on Incucyte® Live-Cell Analysis and fluorescently-labelled antibody fragments. The methodology is amenable to any protein expressed on the cell surface to which there is a corresponding specific antibody.
Morphological and Phenotypic Live-Cell Assays
Ensure the physiological relevance of results and reveal time-dependent treatment effects early in the drug discovery process by providing real-time morphological and phenotypic insight.
Clarification and Filtration
Sartoclear Dynamics® Lab Filtration Kits
Sartoclear Dynamics® Lab kits are designed for rapid harvesting 15 mL to 1,000 mL volumes of cell cultures in the lab, enabling clarification and sterile filtration to be performed in one step. These kits simplify the process by fully eliminating the centrifugation step otherwise needed for clarification. As a result, up to 1,000 mL cell cultures can be efficiently clarified and sterilized in minutes – quickly and easily.
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Concentration, Buffer Exchange and Diafiltration
Vivaflow®, Vivaspin® and Vivapure® Ultrafilters
Perfect solutions for your ultrafiltration needs serving the complete protein ultrafiltration workflow: From concentration and diafiltration of the original protein source, a cell culture supernatant, to final concentration | desalting of the purified protein.
Concentration of Low Molecular Weight Peptides - Concentration of Peptides with Vivaspin 500 Ultrafiltration DevicesPDF | 41.2 KB
Concentration of a Low Molecular Weight Peptide – Concentration of an 8 kDa Peptide Fragment with Vivaspin 6 Ultrafiltration DevicesPDF | 75.7 KB
Particle Removal and Sterile Filtration
Minisart® Syringe Filters
Minisart® syringe filters are ideal for clarification of liquids laden with particles, e.g. for preparation of pharmaceuticals or infusion solutions. Sartorius offers Minisart syringe filters for a wide range of applications. The filters are clean and safe as they are almost free of leachables and extractables. Additionally, they reliably remove particles and microorganisms with no leakage.
Microbial Contamination Control of Cell Cultures
Microsart® RESEARCH Bacteria Kit
Provides rapid detection of total bacteria within 2½ h. Use Microsart® RESEARCH Bacteria for fast and reliable real-time PCR-based detection of bacterial contamination in cell cultures or cell culture supernatants.
Cubis II - Your Balance, Your Way
Highest precision and safe workflows
Cubis II Laboratory balances offer attractive build-in – both hardware (e.g. calibration or leveling) and software (QApps) solutions, modularity and various connectivity options at the highest level of precision. These balances were designed for intuitive operation, aided by intelligent assistant systems which ensure the correct usage of the balance at all the time.
Ergonomic sample weighing with uncompromised accuracy
The great variety of sample holders and weighing pans ensure that samples of various types (e.g. safe-lock tubes, vials, flask, syringes or even animals) can be weighed directly on the balance. In this way workflows can be executed much easier, safer and faster. Made of titanium, not only the highest material quality is guaranteed, but notably the repeatability is not jeopardized because of the non-magnetic properties.
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MYCAP® CCX Cell Expansion System
Reliable aseptic technique for cell culture expansion, MYCAP® CCX has a revolutionary closed design that ensures media feed, inoculation, sampling, and transfers are done aseptically—without the need for a biosafety cabinet.
Sartorius’s lab products for sample preparation are scalable and enable reproducible procedures. Our products cover a spectrum from weighing to sedimentation solutions to ultrafiltration units.
Optimize your sample preparation for accurate and reliable results.
Arium®️ Pro VF or UF with Integrated Ultrafilter and Arium®️ Mini Ultrapure Water Systems with Arium®️ CellPlus Ultrafilter
Designed for efficient removal of endotoxins, RNase, DNase, microorganisms and particles. Provides the highest safety for your critical cell culture applications.
Picus Electronic and Tacta Mechanical Pipettes
Sartorius pipettes of the Biohitfamily are appreciated for their user friendliness and accuracy, as well as their attractive, yet practical design.
For accurate and precise results, you need tips designed to match your pipette. Our Optifit Tips and SafetySpaceTM Filter Tips are designed and manufactured to fit perfectly on our pipettes.
Centrisart® Centrifuge Family
The Centrisart® Centrifuge Family portfolio ranges from very compact and space-saving micro-centrifuges to universally applicable benchtop centrifuges with a total capacity of up to 1,600 mL. Perfect for nucleic acid isolation for PCR testing.