Sartorius MSC Pilot Solution

Scaled-up, automated, high-throughput solution to develop process insight through CPP and CQA correlation to establish a safe, robust MSC manufacturing process

  • Process control: Scaled-up optimal expansion process in controlled cell culture (pH, DO, temperature, stirring speed) with consistent, serum-free, xeno-free MSC medium, low-shear harvesting and 3-hour sterility checkpoints in 0.6 – 2 L volumes
  • Automation: Minimize manual processes using an automated benchtop bioreactor and continuous-flow centrifuge system coupled with walkaway automation flow cytometry and live cell analysis platforms
  • Extensive characterization: Monitor MSC morphology and growth using live-cell analysis and acquire paracrine effect understanding with advanced flow cytometry analysis
  • Process insight: Gain clear actionable results using powerful multivariate data analysis software for real-time MSC process monitoring and quality characterization analytics to correlate CPPs and CQAs
Contact an MSC Therapy Consultant

Univessel®

Automated, scalable benchtop bioreactor system for closed-system 3D MSC expansion (0.6 to 2 L)

MSC NutriStem® XF Basal Media

Defined, serum-free, xeno-free MSC expansion medium to maintain normal morphology, stable karyotype, and trilineage differentiation potential

Flexsafe® 2D

Single-use, low-E&L bags of superior strength and flexibility that meet the highest business continuity requirements and serve media and buffer storage and mixing needs

SoloHill® Microcarriers

Sterile, ready-to-use microcarriers in a variety of formats that support rapid and efficient attachment and growth of MSCs in suspension culture

kSep® Systems

Automated, single-use, closed-system centrifugation system with low-shear, gentle, harvesting for reliable, safe and robust downstream MSC processing at pilot scale

MSCgo™ Differentiation Media

Serum-free, xeno-free MSC trilineage differentiation potential testing (osteogenic, adipogenic, and chondrogenic)

Microsart® ATMP Mycoplasma

3-hour PCR-based kit enables fast and reliable detection of mycoplasma, bacteria, and fungi for in-process testing of MSC-based therapeutics

Mycap® 

One-piece, single-use bottle closure for sterile filling, storage, and transfer of fluids to enable a safe, closed-system MSC production process

Univessel®

Automated, scalable benchtop bioreactor system for closed-system 3D MSC expansion (0.6 to 2 L)

kSep® Systems

Automated, single-use, closed-system centrifugation system with low-shear, gentle, harvesting for reliable, safe and robust downstream MSC processing at pilot scale

iQue® 3

Advanced high-throughput flow cytometry platform for MSC phenotypic analysis and immunomodulation and cytokine profiling assessment

Incucyte® SX5

Automated, real-time, live-cell analysis platform for quantitative insights into MSC health, morphology, proliferation, and function

Incucyte® SX5

Automated, real-time, live-cell analysis platform for quantitative insights into MSC health, morphology, proliferation, and function

iQue® 3

Advanced high-throughput flow cytometry platform for MSC phenotypic analysis and immunomodulation and cytokine profiling assessment

SIMCA®

Powerful multivariate data analysis tool with interactive visualizations, an intuitive interface, and automatable workflows for comprehensive process understanding

Sartorius MSC Pilot Solution Data Sheet Collection

PDF | 34.5 MB

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