Sartorius MSC Optimization and Characterization Solution
An automated, high-throughput expansion and characterization solution that accelerates process optimization through CPP and CQA correlation resulting in a robust, scalable, well characterized MSC production process.
- Process control: Determine optimal expansion in controlled MSC cultures (pH, DO, temperature, stirring speed) with consistent, serum-free, xeno-free MSC medium and 3-hour sterility checkpoints in 100 – 250 mL cultures
- Automation: Minimize manual work with a multi-parallel bioreactor and walkaway automation advanced flow cytometry and continuous live-cell analysis platforms
- At-scale throughput: Optimize your MSC production process in 1 - 8 mini bioreactors operated in parallel and perform cell characterization assays in 96- and 384-well plates
- Extensive characterization: Monitor MSC morphology and growth using live-cell analysis and acquire paracrine effect understanding using advanced flow cytometry analysis
- Process insight: Gain rapid understanding of the optimal MSC expansion protocol using advanced modeling software and quality characterization analytics to correlate CPPs and CQAs
Process Control
Ambr® 250 Modular
Expandable automated benchtop bioreactor system with 2-8 single-use 100-250 mL vessels for accelerated, high-throughput MSC process optimization
MODDE®
Design of experiment software to enable a seamless transition from planar to suspension culture while identifying critical process parameters
MSC NutriStem® XF Basal Medium
Defined, serum-free, xeno-free MSC expansion medium to maintain normal morphology, stable karyotype, and trilineage differentiation potential
SoloHill® Microcarriers
Sterile, ready-to-use microcarriers in a variety of formats that support rapid and efficient attachment and growth of MSCs in suspension culture
MSCgo™ Differentiation Media
Serum-free, xeno-free MSC trilineage differentiation potential testing (osteogenic, adipogenic, and chondrogenic)
NutriFreez® D10 Cryopreservation Media
Fully defined, serum-free cryopreservation medium for a consistent, high-performance protective environment for MSCs during the freezing, storage, and thawing
Microsart® ATMP
3-hr PCR-based kit for the detection of mycoplasma, bacteria, and fungi for in-process testing of MSC therapeutics
Automation
Ambr® 250 Modular
Expandable automated benchtop bioreactor system with 2-8 single-use 100-250 mL vessels for accelerated, high-throughput MSC process optimization
iQue® 3
Advanced high-throughput flow cytometry platform for MSC phenotypic analysis and immunomodulation and cytokine profiling assessment
Incucyte® SX5
Automated, real-time, live-cell analysis platform for quantitative insights into MSC health, morphology, proliferation and function
MODDE®
Design of experiment software to enable a seamless transition from planar to suspension culture while identifying critical process parameters
At-Scale Throughput
iQue® 3
Advanced high-throughput flow cytometry platform for MSC phenotypic analysis and immunomodulation and cytokine profiling assessment
Incucyte® SX5
Automated, real-time, live-cell analysis platform for quantitative insights into MSC health, morphology, proliferation and function
Ambr® 250 Modular
Expandable automated benchtop bioreactor system with 2-8 single-use 100-250 mL vessels for accelerated, high-throughput MSC process optimization
MODDE®
Design of experiment software to enable a seamless transition from planar to suspension culture while identifying critical process parameters
Extensive Characterization
Incucyte® SX5
Automated, real-time, live-cell analysis platform for quantitative insights into MSC health, morphology, proliferation and function
iQue® 3
Advanced high-throughput flow cytometry platform for MSC phenotypic analysis and immunomodulation and cytokine profiling assessment
Process Insight
Powerful multivariate data analysis tool with interactive visualizations, an intuitive interface, and automatable workflows for comprehensive process understanding
