Sartorius T-Cell Screening Solution

A semi-automated solution for multiplexed phenotyping and functional characterization of engineered T-cells for identification of critical quality attributes, CAR construct optimization, and validation of CAR construct screens to enable discovery of markers expressed on target cancer cells and of more potent CAR constructs for established cancer markers with fewer off-target effects.

  • Control variability: Ensure reproducibility of your observations by using consistent serum-free medium, precise pipetting tools, and consistent water as well as by implementing mycoplasma, bacteria, and fungal checkpoints
  • Automation: Perform functional and phenotypic characterization of CAR-T cells to discover high-affinity CAR constructs for specific targets on cancer cells and validate your findings in a flexible assay platform with DoE software package
  • At-scale throughput: Acquire cytokine, phenotype, and function information at throughput with 24-48 sample flexible assay platform, multiplex analysis of cells in suspension, and continuous live-cell analysis in 96- and 384-well plates
  • Extensive characterization: Characterize CAR affinity, potency, and off-target effects through information-rich T-cell phenotyping, cytokine analysis, and T-cell killing assays
  • Insight: Obtain a comprehensive understanding of the CAR receptor and of the CAR-T cell phenotype and in vitro and in vivo function
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4Cell® Nutri-T

Xeno-free, serum-free medium specifically designed for the culture and expansion of lymphocytes

Microsart® Research

3-hr PCR-based kit for the detection of mycoplasma, bacteria, and fungi for contamination control

Ambr® 15

High throughput, automated bioreactor system for 24 or 48 parallel cultivations at the 10 –15 mL microbioreactor scale

MODDE®

Design of experiment software to facilitate translation of data to insights and shift process complexity from the floor to the control room

Picus® Nxt

Ergonomic electronic single- and multichannel pipettes with protocol memory and with adherence to the strictest regulations 

Sartoclear Dynamics® Lab

Out-of-the-box, fast and effortless kit to clarify high-density mammalian cell cultures

Vivaspin®

Ultrafiltration device with unique twin vertical membranes for optimal crossflow, 0.5 to 15 mL

Vivaflow®

Scalable crossflow ultrafiltration concentrator, 100 mL to 5 L

Centrisart® G-16C

High-capacity, refrigerated bench top centrifuge for harvesting T-cells directly in Ambr® 15 buckets

iQue® 3

High-throughput, advanced flow cytometry platform for T-cell activation and cytokine profiling assays as well as multiplexed phenotypic analysis

Octet® HTX

Label-free, ultra high-throughput system for receptor-antigen affinity and kinetics measurement

Incucyte® SX5

Automated, real-time, quantitative, live-cell imaging and analysis platform for T-cell homing (chemotaxis), activation and function assays

Ambr® 15

High throughput, automated bioreactor system for 24 or 48 parallel cultivations at the 10 –15 mL microbioreactor scale

MODDE®

Design of experiment software to facilitate translation of data to insights and shift process complexity from the floor to the control room

iQue® 3

High-throughput, advanced flow cytometry platform for T-cell activation and cytokine profiling assays as well as multiplexed phenotypic analysis

Incucyte® SX5

Automated, real-time, quantitative, live-cell imaging and analysis platform for T-cell homing (chemotaxis), activation and function assays

Octet® HTX

Label-free, ultra high-throughput system for receptor-antigen affinity and kinetics measurement

Ambr® 15

High throughput, automated bioreactor system for 24 or 48 parallel cultivations at the 10 –15 mL microbioreactor scale

MODDE®

Design of experiment software to facilitate translation of data to insights and shift process complexity from the floor to the control room

iQue® 3

High-throughput, advanced flow cytometry platform for T-cell activation and cytokine profiling assays as well as multiplexed phenotypic analysis

Incucyte® SX5

Automated, real-time, quantitative, live-cell imaging and analysis platform for T-cell homing (chemotaxis), activation and function assays

Octet® HTX

Label-free, ultra high-throughput system for receptor-antigen affinity and kinetics measurement

iQue Forecyt® Software

Interactive assay development, analysis, and multiparameter data visualization

Incucyte® Software

Powerful phenotypic cellular analysis, including quantification of dynamic changes in cell subsets and chemotaxis

Octet® Systems Software

Data acquisition and analysis, including kinetics, quantitation, and epitope binning assays

Sartorius T-Cell Screening Solution Data Sheet Collection

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