Sartorius T-Cell Optimization and Characterization Solution

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Sartorius T-Cell Optimization and Characterization Solution

Scaled-up, semi-automated solution to gain process insight through CPP and CQA correlation for the development of a robust CAR-T manufacturing protocol

  • Process control: Determine optimal growth performance and identify critical process parameters with consistent, serum-free, xeno-free T-cell medium and rapid sterility testing in volumes from 100mL to 250mL
  • Automation: Rapidly carry out process development and process optimization with minimal manual handling and online semi-automated monitoring as well as functional and phenotypic characterization of CAR-T cells
  • At-scale throughput: Optimize expansion process in 1-8 bioreactors operated in parallel and perform multiplex analysis in 96- and 384-well plates
  • Extensive characterization: Test for CAR-T phenotypes and functions with multiplex analysis of cells in suspension and profiling in T-cell killing and T-cell health assays
  • Process insight: Analyze process parameters and characterization data in order to correlate CPPs and CQAs
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Ambr® 250 Modular

Expandable automated benchtop bioreactor system with 2-8 single-use 100-250 mL vessels

4Cell® Nutri-T

Xeno-free, serum-free medium specifically designed for the culture and expansion of lymphocytes

MODDE®

Design of experiment software to facilitate translation of data to insights and shift process complexity from the floor to the control room

Microsart® ATMP

3-hr PCR-based kit for the detection of mycoplasma, bacteria, and fungi for in-process and rapid release testing of cell-based therapeutics

Ambr® 250 Modular

Expandable automated benchtop bioreactor system with 2-8 single-use 100-250 mL vessels

MODDE®

Design of experiment software to facilitate translation of data to insights and shift process complexity from the floor to the control room

Incucyte® SX5

Automated, real-time, quantitative, live-cell imaging and analysis platform for T-cell homing (chemotaxis), activation and function assays

iQue® 3

High-throughput, advanced flow cytometry platform for T-cell activation and cytokine profiling assays as well as multiplexed phenotypic analysis

Ambr® 250 Modular

Expandable automated benchtop bioreactor system with 2-8 single-use 100-250 mL vessels

MODDE®

Design of experiment software to facilitate translation of data to insights and shift process complexity from the floor to the control room

iQue® 3

High-throughput, advanced flow cytometry platform for T-cell activation and cytokine profiling assays as well as multiplexed phenotypic analysis

Incucyte® SX5

Automated, real-time, quantitative, live-cell imaging and analysis platform for T-cell homing (chemotaxis), activation and function assays

Incucyte® SX5

Automated, real-time, quantitative, live-cell imaging and analysis platform for T-cell homing (chemotaxis), activation and function assays

iQue® 3

High-throughput, advanced flow cytometry platform for T-cell activation and cytokine profiling assays as well as multiplexed phenotypic analysis

SIMCA®

Powerful multivariate data analysis tool with interactive visualizations, an intuitive interface, and automatable workflows for comprehensive process understanding

Sartorius T-Cell Optimization and Characterization Solution Data Sheet Collection

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