Sartorius T-Cell Exploration and Characterization Solution

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Sartorius T-Cell Exploration and Characterization Solution

Miniaturized, high-throughput, semi-automated solution to acquire in-depth process knowledge through correlation of CPPs and CQAs to identify and optimize CAR-T cells

  • Process control: Control pH, DO, temperature, and stirring speed to optimize culture performance for the selected CAR-T cells using consistent, serum-free, xeno-free T-cell medium along with sterility checkpoints in 15 mL culture vessels

  • Automation: Pre-design experimental setup using DoE software and screen intelligently for optimal expansion conditions to select for specific functional and phenotypic characteristics of CAR-T cells

  • At-scale throughput: Acquire process information using 24-48 vessel multi-parallel screening platform as well as perform cell analysis in 96- and 384-well plates

  • Extensive characterization: Perform T-cell activation, cytokine profiling, T-cell killing, and T-cell health assays with multiplex analysis of cells in suspension and continuous live-cell analysis of cultures

  • Process insight: Develop overall process understanding through the integration of culture performance as well as phenotypic and functional characterization using advanced analytics

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Ambr® 15

High throughput, automated bioreactor system for 24 or 48 parallel cultivations at the 10 –15 mL microbioreactor scale

4Cell® Nutri-T

Xeno-free, serum-free medium specifically designed for the culture and expansion of lymphocytes

Centrisart® G-16C

High-capacity, refrigerated bench top centrifuge for harvesting T-cells directly in Ambr® 15 buckets

Microsart® ATMP

3-hr PCR-based kit for the detection of mycoplasma, bacteria, and fungi for in-process and rapid release testing of cell-based therapeutics

Ambr® 15

High throughput, automated bioreactor system for 24 or 48 parallel cultivations at the 10 –15 mL microbioreactor scale

MODDE®

Design of experiment software to facilitate translation of data to insights and shift process complexity from the floor to the control room

Incucyte® SX5

Automated, real-time, quantitative, live-cell imaging and analysis platform for T-cell homing (chemotaxis), activation and function assays

iQue® 3

High-throughput, advanced flow cytometry platform for T-cell activation and cytokine profiling assays as well as multiplexed phenotypic analysis

Ambr® 15

High throughput, automated bioreactor system for 24 or 48 parallel cultivations at the 10 –15 mL microbioreactor scale

MODDE®

Design of experiment software to facilitate translation of data to insights and shift process complexity from the floor to the control room

Incucyte® SX5

Automated, real-time, quantitative, live-cell imaging and analysis platform for T-cell homing (chemotaxis), activation and function assays

iQue® 3

High-throughput, advanced flow cytometry platform for T-cell activation and cytokine profiling assays as well as multiplexed phenotypic analysis

Incucyte® SX5

Automated, real-time, quantitative, live-cell imaging and analysis platform for T-cell homing (chemotaxis), activation and function assays

iQue® 3

High-throughput, advanced flow cytometry platform for T-cell activation and cytokine profiling assays as well as multiplexed phenotypic analysis

SIMCA®

Powerful multivariate data analysis tool with interactive visualizations, an intuitive interface, and automatable workflows

Sartorius T-Cell Exploration and Characterization Solution Data Sheet Collection

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