Hand homogenisers for sample preparation, e.g. for disruption of tissues or cells of different origin, such as tisssue culture cells, biopsies from spleen, liver, lung or muscle. Even plant tissues can be treated. The classical Dounce type hand homogenisers have a spheric plunger and are available with wide or narrow gap. The Eppendorf vial-shaped manual homogeniser is used for more specific applications.